Technical Integration

LIMS, PACS, and WSI Platform Connectivity

Synthia accepts standard WSI formats from major scanner platforms and offers REST API integration with LIS, PACS, and EHR systems.

REST API EXAMPLE

POST /api/v1/analyze
Content-Type: multipart/form-data

{
  "wsi_file": slide_HER2_001.ndpi,
  "biomarker": "HER2",
  "assay": "standard",
  "report_format": "json+pdf"
}

→ 200 OK in <90s

Supported Formats

Whole-Slide Image Formats

Direct file upload or scanner-connected streaming. Metadata (magnification, scanner model, stain type) parsed automatically.

.svs

Aperio / Leica Biosystems scanner format. Supports SCN multilayer variant. Automatic pyramid extraction.

.ndpi

Hamamatsu NanoZoomer Digital Pathology Image. Including NanoZoomer S360 and S60 variants.

.mrxs

3DHISTECH Pannoramic series scanner format. Includes .dat folder structure. Full metadata parsing.

TIFF / BigTIFF

Standard and BigTIFF whole-slide exports from any scanner platform. OME-TIFF with metadata supported.

DICOM-WSI

DICOM Supplement 145 (Whole Slide Microscopy Image). Compatible with PACS/VNA systems supporting WSI storage.

.scn

Leica SCN400 format. Multi-layer brightfield and fluorescence composite support.

System Connectivity

LIS, PACS, and EHR Integration

Synthia plugs into existing lab IT architecture. No new infrastructure required for basic integration.

REST API

Our primary integration mechanism is a REST API accepting multipart file uploads (WSI + metadata JSON). Analysis jobs are asynchronous with polling or webhook callbacks. Results are returned as structured JSON and/or PDF report.

Authentication via API key or OAuth 2.0 client credentials flow. Per-job audit logging suitable for CLIA lab quality management requirements.

HL7 FHIR R4

For institutions with FHIR-enabled EHR systems, Synthia can output results as FHIR DiagnosticReport resources conformant to the IHC quantification profile. Enables direct integration with Epic, Cerner, and other SMART on FHIR platforms.

DICOM Structured Report

IHC scores can be returned as DICOM Structured Report (SR) objects for storage in a VNA alongside the original WSI. Supports PACS-based review workflows where pathologists open the SR in context with the slide viewer.

Output Formats

  • Structured JSON (full score breakdown)
  • PDF report (pathologist-friendly)
  • FHIR R4 DiagnosticReport
  • DICOM SR object
  • Spatial heatmap overlay (PNG/TIFF)

Performance

  • <90 seconds per full WSI (20×)
  • Batch processing up to 50 slides/day
  • Async jobs with webhook callback
  • Cloud-hosted, no on-premise GPU required

Talk to Our Integration Team

Tell us your scanner platform and LIS/PACS stack. We'll walk you through the integration path and provide API documentation.

Contact Us