Scientific Record

Publications & Abstracts

Preprints, peer-reviewed research, and conference poster abstracts from the Synthia team. Science-first means showing our work in public venues.

RECENT ACTIVITY

2026 USCAP Annual Meeting poster: hybrid CNN-attention for IHC quantification
2025 bioRxiv preprint: multi-biomarker IHC scoring concordance study
2024 USCAP platform presentation: HER2 equivocal 2+ automated flagging

Preprints

Preprint — bioRxiv

Automated Multi-Biomarker IHC Quantification in Whole-Slide Images: A Concordance Study for HER2, PD-L1, and Ki-67

Lin M, Rowan A, Nair P, Chase D. (2025)

bioRxiv · Posted September 2025

doi:10.1101/2025.09.xxxx (preprint link)

Preprint — bioRxiv

Hotspot Localization for Ki-67 Proliferation Index: A Spatial Attention Approach to Automated Pathology AI

Chase D, Nair P, Lin M. (2025)

bioRxiv · Posted June 2025

doi:10.1101/2025.06.xxxx (preprint link)

Preprint — medRxiv

PD-L1 Assay Concordance and the Case for Algorithmic Normalization Across 22C3, 28-8, and SP142 Clones

Nair P, Lin M, Rowan A. (2024)

medRxiv · Posted December 2024

doi:10.1101/2024.12.xxxx (preprint link)

Conference Abstracts & Posters

Poster — USCAP 2026 Annual Meeting

Hybrid Convolutional-Attention Architecture for Automated IHC Biomarker Scoring: Validation Against Board-Certified Pathologist Consensus

Rowan A, Chase D, Nair P, Lin M. (2026)

United States and Canadian Academy of Pathology Annual Meeting · March 2026

Abstract #P2026-0847

Platform Presentation — USCAP 2025 Annual Meeting

Automated HER2 Equivocal 2+ Flagging Reduces Unnecessary ISH Reflex Testing: Results from an Internal Validation Study

Nair P, Rowan A, Lin M. (2025)

United States and Canadian Academy of Pathology Annual Meeting · March 2025

Abstract #P2025-1124

Poster — CAP 2024 Annual Meeting

Intraclass Correlation Benchmarks for AI vs. Pathologist IHC Quantification: What Thresholds Actually Matter?

Chase D, Lin M, Nair P. (2024)

College of American Pathologists Annual Meeting · October 2024

Abstract #CAP-2024-AI-112

Poster — USCAP 2024 Annual Meeting

Reproducibility of Algorithmic IHC Quantification: Test-Retest Concordance for HER2, PD-L1, and Ki-67 in Whole-Slide Image Analysis

Lin M, Chase D, Rowan A. (2024)

United States and Canadian Academy of Pathology Annual Meeting · February 2024

Abstract #P2024-0563

Note on publication status: Preprints have not undergone peer review. Conference abstracts represent work in progress at the time of submission. For the most current validation data, see our Validation page or contact us directly at [email protected].